Follow the instructions specified in the Troubleshooting section at the end of this document. Install the USB drivers on your PC, as discussed above (USB Port Setup).
MPLAB IDE 64-Bit USB Device Drivers Installation file:///C:/PROGRAM%20FILES%20(X86)/MICROCHIP/MPLAB%2. Expanded USB device driver installation instructions may found at: MPLAB IDE installation directoryICD 3Driversddri.htm. 7.3.6 Debug Failure Actions The MPLAB ICD 3 in-circuit debugger was unable to perform a debugging operation.